Replies to post #136198 on Avid Bioservices Inc (CDMO)

[entdoc]

volgoat, good stuff. another arrow in Bavi- quiver.

[biopharm]

Good find Volgoat! Sounds to me like (PS) Phosphatidylserine targeting is becoming that master key to unlocking the immune system or officially now classified by Peregrine here at their Corporate Fact Sheet as an:"upstream immune checkpoint" and .... many are looking for some other possible interaction that works with it in order that they can be utilized by Peregrine. Luckily... Peregrine has been targeting PS for quite some time and hopefully have all bases covered. I like seeing the highlighted section below though... where others are fully aware of the impact that PS has on the immune system... which thankfully Peregrine has 100% all the IP locked down... or locked upstream : )

In addition to this work on phagocytosis, studies on the other potential biological functions of the CD300 receptors will be a major part of our future research. We are particularly interested how PS and PE expression on activated/apoptotic cells regulates the interactions between stimulated T and B cells and myeloid cells (dendritic cells and macrophages), which is key to regulation of the immune response. Integral to this, we will identify the ligands for the other mouse CD300 family members. Of particular interest is whether mouse CD300a (CLM-8), like its human counterpart, and mouse CD300d (CLM-4) and -c (CLM-6) inhibitory receptors, closely related to mouse CD300a, preferentially recognize PE and/or PS or other phospholipids.

www.niaid.nih.gov/LabsAndResources/labs/aboutlabs/lig/receptorCellBiologySection/Pages/coligan.aspx

Interesting weeks ahead...