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Inhibiton

06/05/13 10:58 AM

#56560 RE: Thermoking #56547

The Anandamide Correlation, I love it!. I like seeing article with it mentioned. I've been intrigued by that paticular connection for some time now.

IMO the big understanding you have to have place for the memory side of things is the somewhat mirror relationship between Thc(Tetrahydrocannabinol), and Anandamide(N-arachidonoylethanolamine)!

-Anandamide is soluble in fat which allows it to easily slip across the blood-brain barrier. Its 3-dimensional shape STRONGLY RESEMBLES that of THC. However, THC it's self is a relatively robust molecule, whereas anandamide in comparison is fragile and breaks down rapidly in the body. That is why anandamide doesn't produce the same effects of a continual 'natural high' that you receive from THC.-

-Anandamide is synthesized enzymatically in the areas of the brain that are important in memory, thought processes and control of movement. Research suggests that anandamide plays a role in the making and breaking of short-term connections between nerve cells, and this is related to learning and memory. Animal studies suggest that too much anandamide induces forgetfulness. This suggests that if substances could be developed that keep anandamide from binding to its receptor, these might be used to treat memory loss or even to enhance existing memory! That's why certain compounds synthesized may be good for combating alzheimers too. But in my belief it would one would need to be proactive before a harsh onset of that disease. -