I don't have an exact answer for that. I find more thill in pennies due to the risk for high profits. Though the only benefit I see in big boards are dividend yields, which I find very attractive.
Ok, first off, you can have a thrill ride in the big boards too. There are plenty of volatile moves - look at tlsa, aapl, or unxl the past few days. Big board stocks are not just for divys.
I would like to be able to invest in either, but if I had to lean towards one. I would most likely say pennies.
Let me give you just a little advice about what you just said. Don't ever "invest" in penny stocks. If you want to trade them short term, fine, but don't invest. There are very few good penny companies. The really good ones are few and far between. Don't get caught up in a penny stock and start listening to what they are pumping on their boards. You will lose money if you do that.
I can't pick a strategy for you. This is something you will have to figure out for yourself. I personally am a bounce player. I like to trade big board stocks that are down a certain percentage for a quick bounce play. There are others who play news. They watch the news like hawks and jump on a stock the minute good news hits. Then there are technical traders who don't have a clue what the company does but they watch the charts for a technical move.
I can only offer advice that if you plan on trading pennies be very careful of the promoters, check the filing and watch how big the os is, and if they are diluting. It's a jungle out there.
News 
Market Data 
Discover 
