Replies to post #121696 on Avid Bioservices Inc (CDMO)

[biopharm]

thanks FTM..Bavi PET imaging sounds promising!eom

[EYEBUYSTOX]

Question about pharmacokinetic properties of chemo agents:

Forgive my ignorance, but in theory would the protein binding ability of a specific chemo treatment affect the ability of bavituximab to perform its immune-response inducing activity?

For example, docetaxel and paclitaxel both have >95% protein binding properties and we're seeing some amazing results in combination with these trials (i.e. 2nd line NSCLC and Breast). However, gemcitabine and carboplatin have <10% protein binding, based on my very basic research.

Would Phosphatidylserine fall under the proteins that these chemo treatments include in their "protein binding" effects?

Wikipedia says that "the less bound a drug is, the more efficiently it can traverse cell membranes or diffuse."...but in bavi's case wouldn't the opposite be true as the more binding to PS is what creates the immune response?

I realize this may be a stupid question as my background is not science related, but sometimes it's healthy for discussion to have people who aren't too close to the science make observations IMO.