I understand your logic, but athero posted a while back that there were 133 M opioid prescriptions written in the year in question, and people keep dying. This is a failure of markets.
I also think the hint-of-concept understates the result of the RD trial. They got really solid consistent results that matched animal models. Above all, they got about as robust a result as they could have hoped for out of the trial design, so either the trial design was inadequate to the task, or they got better than hint-of-concept.
In any case this is all moot now. Blood under the bridge.