Of course you are referring to a presidential primary, and I agree it would be tough for Christie if the neocons apply a full court press...but maybe, just maybe, sensible Repubs will emerge and decide they're tired of losing the WH. If not, oh well!
Also, Christie's obese condition could be an issue, along with being thin skinned - his quick (read: sarcastic) one-liners may go over well in NJ where people tell it like is, but nation-wide it may not work as well.