Replies to post #156737 on Biotech Values

[biomaven0]

But up to now, the development of anti-drug antibodies has been associated only with worse efficacy - not (to my knowledge at least) with any sort of severe safety issue. This was a very unusual case indeed - I don't recall seeing another example of a death claimed to be from anti-drug antibodies (as distinct from some sort of anaphylaxis).

Clinical relevance of serum natalizumab concentration and anti-natalizumab antibodies in multiple sclerosis

http://msj.sagepub.com/content/early/2012/09/19/1352458512460604.abstract

Peter