Anyone who argues that what is known about MANF is solely based on the 3 rats doesn't have the slightest idea what's going on. There have been dozens of studies done both in the U.S. and elsewhere that have (since 2003) shown that MANF has the efficacy properties that Dr. John Commisiong presented at the conferences on Jan 8 & 9.
These are carefully done scientific studies that are published in peer-reviewed journals. Read up.