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sdtrond

01/06/13 11:46 PM

#6819 RE: Rawnoc #6818

I notice you don't answer the question, because you can't.

2 person trial:

local progression at 9 months.
ex-hep at 16 months.

TTP (9) is less than PFS (12.5).

How can you argue this?
(of COURSE the numbers can be switched around, that is not the point. The point is you insist it has to be one way and I point out one simple way it can be the other. And local progression ALMOST always will have a lower median time than ex-hep. PLEASE note I'm not talking the number of events, as you tried changing it to once before. I am talking the time TO the events - which is the PFS that HEAT is measuring.)

OK - I am a non-paying member so this is my 15th and last post today. All I'm asking is you answer my question posed above. NOT the Oxford trial, or anything else, JUST THAT QUESTION.

No-dough-go

01/06/13 11:55 PM

#6821 RE: Rawnoc #6818

Again, it states median for LTP is 6 months, IDR is 18 months, and combined (overall) is 11 months which is greater than LTP of 6 months. Therefore, the inclusion of the IDR PFS increases the overall median PFS from 6 (what it would have been without IDR's) to 11.

The only thing the inclusion of IDR's or EDR's does is lower the timeframe of the TRIAL by causing the PFS EVENT MILESTONE to be reached sooner.