"Bulk" ..Large, diffuse , deep cancers are very difficult to rid the patient of, and in the past and still presently, require a surgical attempt, if not too widespread!
Cancer is fought on a 'Multimodal" level, Instituting as Many therapeutic "Vectors" as possible!
"K" would be Instumental in "Debulking" larger masses w/out the need for invasive Surgery, or even as a "Mop Up" of smaller "nodes" after "Primary" location has been Surgically removed!
Then Once a Cancer is reduced to a certain level, other "Treatment protocals" come in to further reduce/eradicate the Cancer, depending on what is being deal With!
fwiw