Replies to post #154459 on Biotech Values

[DewDiligence]

“Once is happenstance, twice is coincidence, three times is enemy action…” What is four times (#msg-63656000)?

[DewDiligence]

Now we know why MRK dumped MK-0524B (Tredaptive+Zocor) a few months ago (#msg-78370229).

[DewDiligence]

MRK Tredaptive post-mortem: Give the FDA credit for rejecting the Tredaptive* NDA almost five years ago and insisting on an outcomes study even though the prior phase-3 trial using lipid endpoints was nominally a success (#msg-30170058, #msg-28864222).

*f/k/a Cordaptive, MK-0524.

[DewDiligence]

MRK/ABT/AMRN—Matt Herper’s musings on the Tredaptive failure:

http://www.forbes.com/sites/matthewherper/2012/12/20/why-mercks-niacin-failure-will-scare-drug-researchers/

[genisi]

Ouch. MRK has dropped plans to seek approval for Tredaptive in the US; in countries where the drug is already approved, sales will presumably plummet.

"MRK is taking steps to suspend the availability of TREDAPTIVE™ (extended-release niacin/laropiprant) tablets worldwide."

http://www.mercknewsroom.com/press-release/research-and-development-news/merck-provides-update-next-steps-tredaptive-extended-rel