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Dimitrios George

12/06/12 2:12 PM

#5485 RE: markkind #5483

Thanks Markkind...I updated the notes (in bold) based on the recent conf calls.

Dawson James notes
Apricus shares have declined this year for several reasons, including but not limited to: 1) An after-effect from
the March 2012 equity raise; 2) A wait-and-see approach by investors related to the financial impact of the
recent acquisitions; 3) Expectations regarding the finalization of pricing and timing of product launch of Vitaros
in Canada; and/or 4) Uncertainties regarding management transition. Interestingly enough, APRI shares are now
trading at levels below our original recommendation in late 2010, and investors can still achieve considerable
share appreciation (100%+) (150%+) at our current price target of $5.50 per share.

the potential catalysts for Apricus for the remainder of 2012 and into 2013 are:
1) Soft Launch of Vitaros in Canada by Abbott (Now happening) (H1/2013) targeted at urologists, more comprehensive launch
later next year (H2/2013) (H1/2013);
2) Approval in Europe for Vitaros (end of 2012 or early 2013), additional potential partnerships signed in
Europe (Spain, Eastern Europe) 2012-2013;
3) Potential response to existing US FDA Complete Response Letter for Vitaros by partner Warner Chilcott
(Nasdaq/WCRX/Not Rated) late 2012 or early 2013, potential US approval 2013;
4) Additional country filings for Vitaros in Latin America and Rest-of-World, particularly Mexico (2012-
2013);
5) Availability of Room Temperature (RT) second generation formulation of Vitaros (Duoject) 2013;
6) Regulatory guidance by health agencies in the US, Europe and Canada for Femprox (H2/2012); DONE but no details yet
7) Regulatory guidance by health agencies in the US, Europe and Canada for MycoVa (H2/2012); DONE for Canada
8) Re-launch of new manufactured batch of Totect (H2/2012), partnerships signed for Canadian and European
markets (2012-2013);
9) Initiation of pharmacokinetic bioequivalency trials for PrevOnco in H2/2012;
10) Initiation of clinical trials by partner Exodos for NexACT ibuprofen drug candidate in 2013; and
11) Filing in Europe and other territories for NitroMist, as well as potentially additional partnership activity for
this recently acquired product.