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genisi

12/06/12 6:45 AM

#153598 RE: biomaven0 #153584

PFE's PD-0332991

This could be a very big product

Absolutely, 1st line in ER+/HER2- is very big and the HR=0.37, 95% CI 0.21-0.63, p<0.001 on PFS is very impressive. Of course, the FDA may want two co-primary endpoints - PFS and OS in phase III.

DewDiligence

12/13/12 11:38 AM

#154027 RE: biomaven0 #153584

JPM analyst projects "only" $1.25B breast-cancer sales for PD-991 in 2020. (Source: Jonathan Rockoff of WSJ.)