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Replies to #208 on Zogenix (ZGNX)
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4ward

12/01/12 2:38 PM

#209 RE: 4ward #208

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GetnGuala

12/02/12 10:53 AM

#211 RE: 4ward #208

was the news yesterday saying the owner dumped 400k shares or disposed of them? those sec forms are hard to understand
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alexander77

12/02/12 3:04 PM

#235 RE: 4ward #208

ZGNX:p values of phase III exterminate short positions

I knew this for a long time, but decided to post this data the week before Adcom as where it was a nuclear bomb to destroy all shorts.

To start: Statistically all p values under p=.05 are significant. The lower the p value the better.

For Zohydro:
1. primary endpoint: chronic pain relief vs placebo
based on average mean changes in daily pain intensity (Numeric Rating Scale)
p=.008

2. secondary endpoint:
2A. Responder Rate Analysis: Significantly higher proportion of patients (%) experiencing improvement in pain relief from beginning to end of study
more than 30% improvement (p<.001!!!!)
more than 50% improvement (p<.001!!!!)
more than 70% improvement (p<.05)

2B. Subject Global Assessment of Medication : Significantly improved overall satisfaction (p<0.001)

You can look at it at the comany's website and the September 2012 presentation
http://ir.zogenix.com/phoenix.zhtml?c=220862&p=irol-irhome