Replies to post #23790 on Ariad Pharmaceuticals Inc fka ARIA

[ariadndndough]

with this post you provided its clear to me that 113 is and will be the better drug. thanks don for pointing out those posts.

http://chicago2012.asco.org/ASCODailyNews/Abstract3007.aspx



at 400 mg humm??????

In the dose-escalation phase of the study, patients received between 50 mg and 750 mg of LDK378 per day. Most patients (83%) received at least 400 mg, the dose thought to be required for clinical activity. The maximum tolerated dose was 750 mg per day, although dose-limiting toxicities were observed in patients receiving 400 mg per day and higher. Common adverse events included nausea (59%), vomiting (54%), diarrhea (48%), fatigue (21%), and dyspnea (16%). Serious adverse events included one case each of transaminase elevation, vomiting, dehydration, and interstitial lung disease. These were all reversible after stopping treatment.