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DewDiligence

10/28/12 5:35 PM

#151395 RE: DonShimoda #151394

Your concern as an ARIA investor is not whether Tasigna, specifically, can cure CML for a significant proportion of patients, but rather is whether any drug (including Ponatinib) can. If CML were to become a non-chronic disease for a significant proportion of patients, the valuation arithmetic on ARIA would have to be adjusted rather drastically.