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DonShimoda

10/26/12 4:36 PM

#151309 RE: jq1234 #151308

Look, I got your point I just don't think it's very convincing.
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DonShimoda

10/26/12 5:02 PM

#151312 RE: jq1234 #151308

Aren't overlapping patients??? Sure that's possible but I think it is far more likely that the TKI failures are from the T315I mutation against which imatinib, nilotinib, and dasatinib are ineffective. The reason I suspect this is that Teva ran a T315I trial and got a 23% response rate (along with some nasty side effects).