Replies to post #100242 on Avid Bioservices Inc (CDMO)

[entdoc]

FTM, nice thoughtful post. Your bottom line was why I asked SK for clarification about other "top priority" disease being looked at for Bavi. His answer was ASCVHD (vascular/heart disease), and Alzheimer's. I can think of many more, especially in the auto-immune category. Maybe you can help with a conceptual/mechanical problem I have with this schematic, and that is, if anti-PS Bavi binds to surface exposed "flipped" -PS, I picture a socket wrench covering a nut perfectly. Are we postulating that Bavi, in covering the -PS site is masking/eliminating a fatal "stay-away" signaling, or do you suppose it is creating a signal that actively recruits the immune cells? It's curious how this type of primary research "spins off" secondary knowledge useful in widely variable fields of endeavor. We're so fortunate to already be there in humans with this platform.

[dia76ca]

I found it interesting to see how Thorpe answered a question about stem cells and leukemia in the Q+A section of the NYAS presentation at 37:43. He sounded positive but it seems they have not done much work on this so far.

I would also love to know more about PS and Alzheimers and heart disease. It is interesting that my doctor has told me that "...what is good to prevent heart disease appears to be good to prevent Alzheimers."