Well, you're going to find shorts lurking in any stock with high volume and a big move upwards. Check out the short volume data here for the past couple of months and notice how much short interest has gone up:
I agree, kind of silly to short APDN during a breakout, but I don't think that whoever was shorting at .19 counted on the entire block of 460K being taken out at once, LOL. He was probably hoping that little nibbles would be taken at .19 and he could cover a couple of cents cheaper. He lost his little gamble and had to cover at .215. Sucks for him, but the guy that went long 460K made about 10 grand. Nice day for him!