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DewDiligence

10/15/12 4:29 PM

#150615 RE: iwfal #150608

The late relapses you’re referring to occurred in the PILOT study, which tested ABT-450/r + ABT-072 (a non-nuke) + ribavirin; i.e. it had no NS5A inhibitor. The study we’re discussing today, called AVIATOR, tested ABT-450/r + ABT-267 (a newer non-nuke than ABT-072) + ABT-333 (NS5A) + ribavirin.

DewDiligence

10/15/12 5:07 PM

#150621 RE: iwfal #150608

ABT—I'd like to see a breakout of G1a vs G1b [in the AVIATOR study]

The breakdown was roughly 2/3 - 1/3. Also, only 30% of patients in the study had the beneficial CC variant of IL28B.