FYI some info on censoring and how it might effect trial results. We have a lot of knowledgeable folks on this board, do the hash marks on the graph refer to censored patients as AF states? Anyone with further information on censoring in this trial would be appreciated.
From Wikipedia, the free encyclopedia
In statistics, engineering, economics, and medical research, censoring occurs when the value of a measurement or observation is only partially known.
The term censoring is used in clinical trials to refer to mathematically removing a patient from the survival curve at the end of their follow-up time. Censoring a patient will reduce the sample size for analyzing after the time of the censorship. Reducing the sample size always reduces reliability, so the more patients are censored and the earlier they are censored the more unreliable the results are.
Many clinical trials are designed with a minimum follow-up time. This means that the results aren't reported until that amount of the time after the last patient signed up for the trial. Often reports of the preliminary results don't include any minimum follow-up time and include the patients with very short follow-up time which definitely affects the reliability of the result.
Point censoring is said to occur when despite continuous monitoring of outcome event, the patient is lost to followup or the event does not occur within the study duration. It is also known as right censoring which can be either end-of-study censoring or loss-to-follow-up censoring. An individual is said to be left censored if the patient had been on risk for disease for a period before entering the study. However, left censoring is usually not a problem in clinical trials, since starting point is defined by an event such as entry of patient in trial, randomization or occurrence of a procedure or treatment.
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