As I indicated yesterday jg - I suspect that IF there were disticnt significant toxic effects to using the NNVC nano-delivery system, we would have seen them by now.
The polymer chemistry to which the specific ligands is bound to make an active viruscide is fairly well characterized and generally regarded as non-toxic.
The effects (long-term) of having this set of polymers introduced into a circulatory system in a long-lived animal - like a person - and seeing those effects monitored over time is an unknown. Unfortunately (and as will many promising medications) long-term effects are hard to predict from short term studies unless there is an obvious and acute reaction. More subtle changes and effects can be missed.
Also - there may be some unknown genetic factor or factors in a large and diverse human population that modulate a response to even a fairly innert substance. To look at a laymans' example that might illustrate this sort of problem - think about people who are lactose intolerant, or who have gluten sensitivity. Most people can drink milk or eat wheat products as a matter of course. People with these intolerances have very different reactions to these otherwise edible substances. Unless a large number of people have been exposed to the product, we don't have a handle on how widely tolerated it will be. There may be a subset of people who (to propose a hypothetical example) have a difference in their kidney or liver function that doesn't allow them to clear the polymers from their bloodstream.
I don't mean to come off as some sort of 'negative nellie' - but the reality of drug testing and validation of a new medicine is that you never really know how good or bad a new drug or treatment is until it is put into widespread use. We'll have a good idea how well the system works once through Phase II and TOX studies. We'll have a much more refined idea after Phase III clinical testing. And things still could go wrong afer we hit the market,... although I will likely have sold at least some of my shares by that point,... so some profit will be made.
Sorry for the ramble,... sometimes I get too long-winded when talking through things like this.
*disclaimer - I am a geneticist/molecular biologist, but have never actually been involved in drug testing or development. So take what I type with at least a hint of sketpicism*
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