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jq1234

09/04/12 11:57 PM

#148201 RE: mcbio #148200

Genzyme is not testing Mozobil in oncology indication at all right now. Those trials are all investigator sponsored trials. The article you linked said all 46 patients with CR, which I know for sure is wrong. Check original article in Blood.

genisi

09/05/12 10:07 AM

#148228 RE: mcbio #148200

I find the fact that there are several compounds (peptide/nonpeptide antagonists, RNAi, or anti-CXCR4 mAb*) targeted to block the SDF-1/CXCR4 complex in clinical trials good for BLRX in the sense of validating the MOA.

http://www.ncbi.nlm.nih.gov/pubmed/22376154

* BMS-936564 isn't mentioned in the abs.