Replies to post #88155 on Avid Bioservices Inc (CDMO)

[freethemice]

You might want to brush up on antibodies. The part that is cut off is the constant
region which would bind to the Fc-gamma receptors on macrophages, dendritic cells.
The imaging agent, NIR, or I-124 is attached chemically to the F(ab')2 part.
So PGN650 has two Fab arms which are both specific for the epitope on domain 2 of
the beta2-GPI molecule which binds to PS. PGN650 does then mask PS and would have
immunomodulating properties, but it would not have the ability to bind to effector
immune cells. I also think the dose used for the imaging may be less than the
therapeutic dose used with bavi. Good night.
http://en.wikipedia.org/wiki/Antibody
http://en.wikipedia.org/wiki/Fab_region