PCYC (still the drug to beat; more data on Monday morning). We learned more details of PCYC’s registration path, with two Phase III trials in relapsed CLL (Ibrutinib monotherapy vs. ofatumumab and combination therapy with bendamustine / Rituxan). A newly described potentially registrational Phase II trial tests single-agent Ibrutinib in Velcade refractory MCL and could offer a fast path to market. Competitive data from GILD and CELG still favors Ibrutinib as the drug to beat, and while GILD plans a Phase III trial of GS-1101 in combination with Ofatumumab in Q3:12, PCYC’s trial could replace Ofatumumab in second-line CLL.