Gandalf, Just wondering if you remember the company giving details about the the mechanism responsible for the paresthesia/tingling side effect with PMX-30063? In the presentations they said they had the mechanism fully characterized.
I wasn't following PYMX that closely in 2010/11, and the only recollection I have was that the paresthesia was due to a change involving potassium ion balance, which caused the transient change in nerve transmission responsible for the tingling/numbness.
Over on the Yahoo board, one of the bashers brought up the topic of the hypertension side effect, and the possible relation to protein metabolism. While PMX-30063 is not a protein and isn't involved in protein metabolism (dietary-wise), it does bind to a portion of the protein binding site found on the bacterial cell wall where the human defense proteins normally bind. So it got me thinking whether the hypertension side effect could conceivably be caused by PMX-30063's binding to a protein binding site in the body that is involved in regulating blood pressure, say an enzyme binding site within the angiotensin system for example.
Another possible or related mechanism for the observed hypertension might involve potassium ions, since we know PMX-30063 affects potassium ion balance to some extent (leading to the paresthesia/tingling), and changes in potassium and sodium ion levels affect blood pressure (see below). Or perhaps PMX-30063's effect on neural transmission also affects neural pathways to the vasculature, thus leading to blood pressure changes.
I'd be interested if you have any additional info. Thanks.
>>> Renin-angiotensin system (RAS): This system is generally known for its long-term adjustment of arterial pressure. This system allows the kidney to compensate for loss in blood volume or drops in arterial pressure by activating an endogenous vasoconstrictor known as angiotensin II.
Aldosterone release: This steroid hormone is released from the adrenal cortex in response to angiotensin II or high serum potassium levels. Aldosterone stimulates sodium retention and potassium excretion by the kidneys. Since sodium is the main ion that determines the amount of fluid in the blood vessels by osmosis, aldosterone will increase fluid retention, and indirectly, arterial pressure. <<<
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