Even more unfortunate that it takes an investor to decipher the results. It would have been far better if management had relayed it in the first place.
As with Vancomycin, bacterial resistance can develop to most regular antibiotics, including Daptomycin (see below), and the more Daptomycin is used globally, the more resistance will eventually develop. This is because of their biochemical mechanism of action, vrs the biophysical mechanism of PMX-30063/defensin mimetics.
The total lack of resistance developing will be the biggest advantage of PYMX's defensin mimetic antibiotics, along with extremely short dosing. PMX-30063 also has a much broader spectrum of activity - gram positive and gram negative bacteria (Daptomycin is only effective against gram positive). Also, unlike Daptomycin, PMX-30063 is effective in the lung -
>>> Genetics of Antimicrobial Resistance in Staphylococcus Aureus : Resistance to Daptomycin
Resistance to Daptomycin
Daptomycin is a lipopeptide class antibiotic that consists of a cyclic hydrophilic depsipeptide attached to a fatty acid chain.[161] In the presence of calcium ions, daptomycin changes conformation and inserts into the lipid bilayer, causing cell membrane depolarization via leakage of potassium ions and other cytosolic constituents.[162,163]
Daptomycin treatment failures have been noted since 2005,[164,165] however these are rare and the mechanism of resistance appears to be multifactorial and not clearly defined. As mentioned above there is some correlation with intermediate vancomycin resistance and in vitro experiments have also established that chromosomal mutations in mprF (encoding a lysylphosphatidylglycerol synthetase), yycG (encoding a sensor histidine kinase), and rpoB and rpoC (encoding the ß and ß' subunits of RNA polymerase, respectively) affect daptomycin susceptibility.[166] In addition, mutations in mprF and yycG have been identified in resistant clinical isolates, and although the affect of these mutations is not well understood, the former most likely influences the phospholipid content of the cell membrane
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