chees,yours is the question of the WEEK. Folks,are we still about moving closer to the goal line? Shake it off and hit the next defensive line with dynamite. PPHM has that and more in the closet. Think data points. PPHM has human "numbers", and in spades, for its anti-PS MAB Bavituximab. Safety. Unquestionably immunostimulatory. Talk it down? Not. Bavi didn't budge metastatic lung cancer. Duh. Like asking an agile dancer to take out Godzilla. Anyone still posting here who is retail? Haloooo! Anyone posting here who isn't short? Splitting hairs... comparing naked chimeric Bavi- with dittoed Avastin is comparison with a dead duck. Anyone know where we are right now with all-human MABs being used for solid cancers, and not chimerics? Do MABs have a role in treating solid tumors? If so, then Bavi- deserves a place in the MAB mix. Tumor immunology. We have known early 70's tumor immunology of BCG vs. melanoma that these agents are nicely synergistic and sometimes even curative if used early enough in a relatively intact immune system. No surprises here. Now we have that agent. Oral Bavituximab. A nasal spray? Yes. Fantasy? No. It's all there in the peer-reviewed medical literature, nasal spray and all. Chimeric Bavi- is outdated in favor of all-human Bavi. Gird your loins. Get over it. We know how it works on the immune system. And it DOES work. And we know from increasing human trials experiments that it is amazingly safe. The all-human Bavi will not have the allergic risk for repeat dosing that part mouse-part chimeras have. That means earlier and longer dosing. A no-brainer: a safe immunostimulant with low side-effects. I think Bavi is going to be useful. Who's trying to fool whom? A fully humanized Bavi pill with radiotherapy seems almost a certainty. Increase those monocyte scavengers and immunocytokynes when it really helps the fight cancer. We've established that Bavi is not an end-of-life drug. That's about all. Knock it out of the arena? I don't think so. If that happens, I want to keep my fair share of the technology. Probably not the time to give up on this one. I've done that once too often. PPHM has a stable of winners. MAB delivery of RAI? PPHM has it. Need I repeat? It's scientists are the best. The medical pharmacology department of UTSW is simpy stellar, and the bench folks at Avid and PPHM are the pick of the crop. Massive layoffs? There are 154 employees poised to gear up, and the company is still hiring. What are we doing to help?
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