Replies to post #138135 on Biotech Values

[glass_half_full]

Columbus & primary endpoint

I can't wait to hear the answer, but it's a bit like saying that "Pfizer didn't discover Viagra, because their primary endpoint was angina."

I'd be more willing to accept the formulation that "Statistically, Columbus' voyage was a failure because his primary endpoint was India."

[jq1234]

Astex CEO Mohammad Azab.

[MadCityCyclone]

Yogi Berra? GW? Romney?

[jellybean]

I believe it was Stephen Senn...

Here's the full quote and reference:

The definition of a medical statistician is one who will not accept that Columbus discovered America because he said he was looking for India in the trial plan.3 Columbus made an error in his power calculation—he relied on an estimate of the size of the Earth that was too small, but he made one none the less, and it turned out to have very fruitful consequences.

Senn SJ. Statistical issues in drug development. Chichester: Wiley; 1997. p. 58.