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genisi

02/16/12 1:09 PM

#137142 RE: oc631 #137140

I'm not saying Pharmasset scientists were not aware that PSI-938 was active against 282T mutant, rather I'm saying they didn't design it to be so and were surprised to see its activity there. The fact that the work I referenced was published in March 2011 doesn't mean they didn't know that earlier, but if you read the paper it is clear that PSI-938 by its structure was not supposed to be active against the 282T mutant.