Replies to post #137085 on Biotech Values

[iandy]

Peter - Am I correct in inferring from your comments that a 113 phase 2 would be comprised of crizotinib failures?

[genisi]

Doebele et. al. also found diverse mechanisms (even two different ones in one lung cancer patient's tumor) of acquired resistance to crizotinib:

http://www.ncbi.nlm.nih.gov/pubmed/22235099

Also in the same issue of Science Translational Medicine where Katayama published (posted by ariadndndough in #msg-72153321), there is a good overview (I have the paper if you or anyone wants to read):

http://www.ncbi.nlm.nih.gov/pubmed/22323827