It's hard for me to come up with a $400mm peak sales scenario that's realistic. If sprycel/tasigna continue to take 1st line market share, pona will end up capturing an even greater share of the 2nd line market which is approaching $1 billion, today. Even if gleevec (or its generic) is able to maintain its first line market share, the anticipated confirmatory study should position pona well in 1st line high-risk pts in addition to T315I which, combined with high-risk pts, could readily generate 400MM alone.