Replies to post #132204 on Biotech Values

[genisi]

So there are in vitro antagonistic drug-drug interactions

Depends on cell type (replicon cells or HHPC) and donor. But the relevant part is this:

"Therefore, even in the presence of telaprevir at 10-fold the Cmax, the concentration of PSI-7409 in primary human hepatocytes was greater than 30 times the Ki of PSI-7409 for the NS5B RdRp. For that reason, our in vitro results suggest that it is unlikely that co-dosing of telaprevir would affect the antiviral activity of PSI-7851 or its diastereoisomer, PSI-7977, in the liver."