Interesting this was on WebMd, and actually talks about one dose of 450...
Increasing the Dosage Above 300 mg/day
As with other antidepressants, the full antidepressant effect of WELLBUTRIN XL may not be evident until 4 weeks of treatment or longer. An increase in dosage to the maximum of 450 mg/day, given as a single dose, may be considered for patients in whom no clinical improvement is noted after several weeks of treatment at 300 mg/day
Doses of WELLBUTRIN XL (bupropion hydrochloride extended-release) above 300 mg/day have not been studied for the prevention of seasonal major depressive episodes