Not necessarily as Gleevec was tested on top of at least 2 medications as an add-on therapy in patients with more advanced disease:
Criteria Inclusion Criteria:
Current diagnosis of pulmonary arterial hypertension according to the Dana Point 2008 meeting PVR = 800 dynes.sec.cm-5 despite treatment with 2 or more specific PAH therapies: endothelial receptor antagonists, phosphodiesterase 5 inhibitors, and prostacyclin analogues WHO functional class II - IV 6 MWD = 150 meters and = 450 meters at screening