Replies to post #11752 on Biotech Values

[cooldrinkh2o]

<<Theoretically, the technique suggests that you can create an anti-inflammatory cytokine response using this method. However, in the JACC paper none of the cytokines that they measured in this trial were significant between the treatment and placebo arm. So that raises the question whether or not the method is working in practice as they think it is in *theory*.>>

Excellent point and thank you for the study review.

Not knowing much about cardiology I could use your help with the following:
The Forbes article implied that the reduction in cardiac events was due the fact that Celacade reduced inflamation in the arterty walls i.e. "When artery walls get inflamed, they eventually cause fatty plaque to rupture and block flow to the heart."
This MOA on the surface does not seem like it would improve EF, but would rather reduce the incidence of further events (I did not read the study and am assuming that EF declined similiarly among survivors in both arms, but more people died from MI or other cardiac events in the placebo arm due to the increased inflamation). Is that plausible?

[iwfal]

Inre VSGN: The concept of inflammation being important in the etiology of heart disease relates more to the infiltrating cells in the myocardium releasing pro-inflammatory cytokines. This method would not stop that signaling, as far as I understand. Also, the absence of an effect on the ejection fraction is troubling. The ejection fraction along with the treadmill test (not different between groups) were the two measures that best reflected a direct treatment effect in this trial.

It appears that Celacade's MOA for CHF is not physical (ejection fraction or treadmill) but electrical. If so it would not be alone - e.g. Eating a lot of fish does not significantly reduce the number of heart attacks but it is pretty clear that it reduces the number of deaths (probably by improving in some way the electrical function. Anyone know how people with CHF normally die - Fib?

BTW - The biggest concern with this MOA is that it is not obvious how it applies to their other ph iii in PAD.