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06/06/11 9:03 AM

#121066 RE: DewDiligence #121054

Alimta was approved by the FDA and EMEA as a front-line nonsquamous NSCLC maintenance therapy 2 years ago (#MSG-39303562) and the continuation maintenance setting makes even more sense. Tareceva was approved in the front-line NSCLC maintenance setting a year ago (#MSG-49106892), but as you noted we should not expect that this will increase sales.
Rituxan is a case in point where sales in NHL has increased a lot by use in the maintenance setting.
Revlimid might have good* maintenance opportunity in the post autologous stem cell transplantation setting where therapy could last few years and is also being tested in phase III as a maintenance therapy for post R-CHOP in DLBCL.

*Tox, specificaly neutropenia and the risk for new malignancies could of course stop or lessen long term use with the drug.