Replies to post #7683 on Ariad Pharmaceuticals Inc fka ARIA

[BTH]

I thought I read in a scientific journal somewhere (can't truly recall) that one of the ridaforolimus combination trials (with a Merck drug) in solid tumors showed efficacy in an endometrial subset (amongst others).

I'm sure this is the debate in Merck right now. Go solo, or go combo. And, the dinosaurs at Merck will send it through 24 different committees and one blue ribbon panel for 4 years to figure out which one to do.

[DonShimoda]

I'm wondering if there are any late phase m-tor combo(or multitarget single drug) trials already underway that would discourage them

Not sure about that but I seem to recall reading that a major endometrial trial was recently stopped for lack of efficacy.