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mdphd1

03/03/11 9:46 PM

#46952 RE: BonelessCat #46944

""The most effective FluCide candidate demonstrated a fifteen-fold (15X) greater viral load reduction as compared to Tamiflu(r) (Roche), and a thirty-fold (30X) greater viral load reduction as compared to untreated animals.

Treatment with both FluCide candidates and Tamiflu commenced 24 hours after the initial viral infection. Tamiflu was administered orally twice daily at 20mg/kg (i.e. 40mg/kg/day) while the nanoviricides were intravenous injections at 100mg/kg every 48 hrs."

This is difficult to interpret, because its not clear for how many days the drugs were given. Assuming that the drugs were given for the same number of days to a 200 g mouse, 16 mg of Tamiflu was given every 2 days, and 20 mg of Flucide was given every 2 days. Thus you can see that more Flucide than Tamiflu was given on a weight basis. Flucide is however obviously more effective, as measured by viral load reduction.