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mcbio

03/02/11 8:31 PM

#115768 RE: mcbio #115634

TSRX @ Citi (3/2/11 slides)

http://files.shareholder.com/downloads/ABEA-43S70D/1040841912x0x445480/027dd251-86e5-4fba-a358-d39cecf58561/Trius_Citi_Presentation_3-2-11.pdf

I don't see an audio replay of this presentation on TSRX's Web site, so just a few new notes from the slides as follows:

1. Slide 18 (Future Objectives) - sign an ex-U.S. commercial partnership for torezolid phosphate. This tells me that TSRX hopes to be able to keep U.S. rights for itself.

2. Slide 19 - cash runway extends to 3Q12.
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mcbio

04/11/11 7:21 PM

#118079 RE: mcbio #115634

TSRX - torezolid phosphate patent extension

http://finance.yahoo.com/news/Trius-Announces-Patent-Term-pz-1324899139.html?x=0&.v=1

Trius Announces Patent Term Extension for Torezolid Phosphate
Provides U.S. Patent Exclusivity Through Early 2028

SAN DIEGO, April 11, 2011 (GLOBE NEWSWIRE) -- Trius Therapeutics, Inc. (Nasdaq:TSRX - News) announced today that the Company has received official notification from the U.S. Patent and Trademark Office that U.S. Patent No. 7,816,379 which covers the composition of matter of torezolid phosphate (TR-701), the Company's lead investigational drug, has been extended by one thousand one hundred sixty-three (1,163) days. The patent term adjustment granted by the U.S. Patent and Trademark Office extends patent coverage in the United States on torezolid phosphate until February 23, 2028.

"A strong and long-lived intellectual property position has significant implications for the commercial value of torezolid phosphate," said Jeffrey Stein, Ph.D., President and Chief Executive Officer of Trius. "This patent term extension of over 3 years provides Trius with over 17 years of exclusivity in the U.S. from the start of our Phase 3 clinical program and will enable us to optimize the commercial potential of torezolid phosphate."

Trius acquired worldwide rights outside of North and South Korea to a family of patent applications that provide patent coverage for composition of matter and methods of making and using torezolid phosphate through an exclusive license from Dong-A Pharmaceuticals in 2007. Counterpart applications have previously been granted in Australia, India, New Zealand and Russia. Additional counterpart applications are under review in other countries. In addition to the U.S. patent and the four allowed or issued foreign patents mentioned above, Trius has filed patent applications directed to other aspects of torezolid phosphate discovered by Trius' scientists. Should these applications issue, patent exclusivity for such aspects of torezolid phosphate would extend through 2030.

About Trius Therapeutics

Trius Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of innovative antibiotics for serious, life-threatening infections. The company's lead investigational drug, torezolid phosphate, is an IV and orally administered second generation oxazolidinone in Phase 3 clinical development for the treatment of acute bacterial skin and skin structure infections (ABSSSI), the first such trial to be initiated under a Special Protocol Assessment (SPA). In addition to the company's torezolid phosphate clinical program, it is currently conducting two preclinical programs using its proprietary discovery platform to develop antibiotics to treat infections caused by gram-negative bacteria. For more information, visit www.triusrx.com.