when your predicted lung function is 64% of normal due to disease, and you get an absulute increase of over 10% you are getting some serious clinical benefit. its easy to see in a relative sense the benefit was >10% (10.5/64x100=16+%), and if you consider that a 35% absolute increase puts you at 100% predicted or equal to those with no disability whatsoever, you see that this drug essentially gets you a third of the way there another perspective on the clinical benefit - 80% predicted is usually considered the lower bound of normal - pts on drug got to 75% it wouldn't surprise me if these people end up living decades longer because of this drug