GNVC
I got lucky - was asked by my dad's estate to clean up a biotech portfolio of three stocks worth low, low, low 6 figures which had only 3 names, none of which I really knew very well, and of what I did know, I only liked one, somewhat.
I got good advice from contacts (including rkrw - thanks rkrw) and began to slowly ease the stocks out as they were all running (this was late 2009). I began to think I was an idiot because I had sold half of each of the main two components of the portfolio and the stocks had doubled (GNVC and EMIS) and I did not like either. Anyway I blew out of the rest of GNVC and then it went up another 10% or so before collapsing. EMIS - not so lucky as I got caught with a tag-end of 10-15% of the shares when they finally collapsed. For awhile it looked stupid, but it turned out pretty well measured by avg realizations vs. his cost basis and the price at time of beginning to liquidate. The portfolio more than doubled. No one would have questioned me if I had just blown them out but so much better the way it turned out. You have to take what the markets give which is what some of these perma-bears just don't get.
Jon