Replies to post #114818 on Biotech Values

[DewDiligence]

But note the local radiologists were also (in theory at least) blinded here.

Like a professional poker player, an experienced clinical-trial investigator has learned how to interpret the subtle “tells” that would be missed by most people but can render the blinding of a trial less effective.

[bellweather1]

Thanks Peter, DD, PGS, for your thoughtful responses.

I also assumed that the local radiologists were (at least technically)blinded.

But what I'm still not clear on is, is it possible, in view of the inflamatory processes that surround successful tumor diminution via medication, that IRC radiologists were more likely to interpret small tumor size increases(possibly due to inflamation associated with regression)as a sign of progression, versus the locals, who may have access to a wider range of interpretive measures?

Or, is the difference between pre-regression based inflamation vs actual tumor growth fairly easily differentiated (e.g. due to differences in the density of the sections in question)?

Thoughts?

Thanks again,

bw