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03/31/05 6:24 PM

#17862 RE: Paulness #17810

Paulness: The speed with which CYGX has been able to proceed with regard to the anti bacterial vs Staph compound is encouraging. In the past antibiotics were found by locating fungi, isolating compounds from them and refining them to potential drug candidates. These traditional antibiotics attacked the bacterial cell walls, etc...and all have been eventually rendered useless or at least less effective due to the development of resistance. And the process took years and years to develop an antibiotic that is safe and effective. CYGX is going directly for the bacteria's genes..to render it unable to reproduce. This could put CYGX at the forefront of anti-bacterial therapy in the 21st century. I own many shares of another company, AVII, that can take out any single strand RNA virus...they are currently taking on Hep C, Dengue fever, Marburg virus, Ebola virus, and West Nile virus. And the similarity to CYGX is that AVII, once a virus's genetic structure is known, can produce an antisense compound in 2 weeks to defeat the virus. The federal government is doing some of the testing for them...a potential bioterrorism player. I am not pumping for AVII...I only reference them because of the speed with which they and CYGX are able to go from defining a target based on the genetic sequence and the development of a compound to defeat the target. We are at the advent of a truly remarkable age of drug discovery. CYGX longs, put the naysayers on ignore and keep the faith. CYGX continues to make progress, and I think today's press release shows that they are giving the anti-bacterial compound the utmost priority. I think the herpes cream will be less important to the future of CYGX and the management knows it and are acting accordingly.