IMHO, even more important, is that preliminary phase I results indicate, that Pona can arrest/block the T315I mutation from mutating in the first place. In other words, with Pona, you lessen the chance in developing the T315I mutation. Read that information in the last Pona update. That will certainly cause Pona to move to the first level of treatment for certain CML patients. Some doctors will provide their patients the Lexus treatment..