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noretreat

11/16/10 9:00 AM

#41655 RE: Doctor_Hari_Seldon #41653

My understanding is that the Tamiflu was administered based on the "generally accepted best practice". I believe the first PR on flucide talked about that.

Some verbage in the PR's could spell that out each time to avoid confusion

BonelessCat

11/16/10 9:02 AM

#41657 RE: Doctor_Hari_Seldon #41653

TamiFlu IV was only recently approved and for limited use in critical care. It is not the standard prescribed to patients. Oral Tamiflu is still the standard. If you read the literature, Tamiflu IV is actually less effective than oral Tamiflu, but in some cases oral Tamiflu can't be administered (comas come to mind), resulting in a need for an injectable version.

Second, oral Tamiflu is designed to process through the liver, and that was the original challenge during development in making the neuraminidase inhibitor effective. The criticism is flawed (maybe ignorant is a better term) that it is somehow unfair to pit an oral drug against an injectable due to liver processing.

Third, the original tests that the optimized FluCide expand upon were performed with oral Tamiflu. Moreover, as oral Tamiflu is still the standard 3 years later the test is perfectly valid and the results reliable. Tamiflu oral or injectable both only reduce flu duration in humans and mice alike by one and a half days.

WILD_4_IPIX

11/16/10 9:34 AM

#41668 RE: Doctor_Hari_Seldon #41653

I see where DR FG has responded already. Thanks Doc !