Replies to post #2711 on Ariad Pharmaceuticals Inc fka ARIA

[BTH]

I'm not disagreeing with you.

I'm disagreeing with a posters previously absurd response that there is NO feedback loop in Afinitor or Torisel (which is an outright lie).

Considering this is directly from Novartis' Afinitor:

"

Mechanism
In a similar fashion to other mTOR inhibitors its effect is solely on the mTORC1 protein and not on the mTORC2 protein. This can lead to a hyper-activation of the kinase AKT via inhibition on the mTORC1 negative feedback loop while not inhibiting the mTORC2 positive feedback to AKT. This AKT elevation can lead to longer survival in some cell types.

"