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DewDiligence

10/20/10 2:13 AM

#106684 RE: DewDiligence #106656

#msg-55725398 has a quiz that’s easy enough for almost anyone on this board to get the answer, while still being hard enough to make one have to think. Any takers?

genisi

10/20/10 11:19 AM

#106723 RE: DewDiligence #106656

Why open-label

GILD thinks that high rate of virological failure seen in the completed phase-3 trials could have resulted from low compliance of patients, who had to take many pills a day (trials were double blinded and placebo controlled). In the new Bitripla vs.Atripla every one gets fixed-dose once a day and I believe the B is a smaller pill than A (because TMC278 25 mg is smaller than 600 mg for Sustiva), so it's an open trial and everyone knows what they are getting.