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randychub

10/18/10 10:22 PM

#106559 RE: DewDiligence #106553

Bicon - I see part of their Robust product line includes BIOMAb-EGFR™. This is same EGFR drug (nimotuzumab) YMI is very slowly developing.

- BIOMAb EGFR® voted ‘Bio-Spectrum Asia-Pacific Product of the year’, 2008

The sales of diabetology division increased by 24 per cent, oncology segment by 59 per cent with brand Abraxane and Biomab EGFR as key contributors.


R

jq1234

10/19/10 4:36 PM

#106608 RE: DewDiligence #106553

The side effect of this deal is NVO, down 10% in two days:

Biosimilar threat tarnishes Novo's star status

COPENHAGEN/LONDON, Oct 19 (Reuters) - Fears of cut-price competition in the insulin market sent shares in Novo Nordisk (NOVOb.CO) skidding again on Tuesday, lopping some 10 percent off the Danish drugmaker's market value in less than two days.

The threat from so-called biosimilar insulins has been crystallised by Pfizer's (PFE.N) agreement to sell versions of insulin developed by India's Biocon (BION.BO). [ID:nSGE69H0I8]

Piper Jaffray senior analyst Sam Fazeli said the news was a sudden reminder of the likelihood of generic insulin competition in a few years' time and shares in Novo -- the European drug sector's star performer this year -- could drop even more.

"The real risk from generic insulin is far out, but Novo's valuation was so high it was vulnerable," he said.

"They are taking a hit because they are the most expensive pharma company in the world. In order to have that kind of valuation, you need to have a business that is bullet-proof."

Fazeli, who has a neutral stance on Novo's shares with a price target of 495 crowns, added that if Biocon had made a deal with any drugmaker other than the world's biggest "maybe people wouldn't have been so worried".

The Danish drugmaker, the world's biggest supplier of insulin, has been on a roll since mid-2009 on hopes for its new diabetes drug Victoza and confidence in its insulin franchise.

Expanding waistlines globally have fuelled an epidemic of type-2 diabetes that has boosted demand for its products.


http://www.reuters.com/article/idUSLDE69I0ZK20101019

DewDiligence

10/20/10 7:54 AM

#106697 RE: DewDiligence #106553

PFE Acquires 40% Stake in Brazil’s Teuto for $240M

[Here we go again: PFE’s second deal this week to bolster its presence in branded generics in emerging markets. (PFE’s previous deal this week was with Biocon for insulin biosimilars: #msg-55680051.) Teuto is one of the largest vendors of generics and branded generics in Brazil, which is one of the world’s top-10 largest pharma markets. According to this PR, generics and branded generics comprise 60% of the Brazilian pharma market by sales (as opposed to unit volume), a much higher % than in the US and EU.

PFE will pay 400M reais ($240M) up-front for 40% of Teuto with a call option on the other 60% of the company exercisable in 2014 and a put option by Teuto shareholders for the other 60% exercisable in 2015.

#msg-50473238 is a must-read companion piece.]


http://finance.yahoo.com/news/Pfizer-Enters-Into-Agreement-prnews-1554844301.html?x=0&.v=1

›Wednesday October 20, 2010, 7:00 am

• Pfizer Enters Into Agreement to Acquire 40 Percent Stake in Teuto in Brazil

• Transaction will expand portfolio of generic medicines in Brazil

• Partnership will increase Pfizer's ability to deliver high-quality medicines to more patients in Brazil

• Builds on Pfizer's commitment to seize growth opportunities in key emerging markets

NEW YORK, Oct. 20 /PRNewswire-FirstCall/ -- Pfizer Inc. (NYSE:PFE) announced today that it is entering into a partnership with Laboratorio Teuto Brasileiro S.A., a leading company in the Brazilian generics industry, to develop and commercialize generic medicines. Pfizer will acquire a 40 percent stake in Teuto and the companies will also enter into a series of commercial agreements. The partnership will enhance Pfizer's position in Brazil, a key emerging market, by providing access to Teuto's broad portfolio of approximately 250 products in more than 400 presentations. Through this partnership, Pfizer will have access to significant distribution networks in rural and suburban areas in Brazil and the opportunity to register and commercialize Teuto's products in various markets outside Brazil. In addition, Pfizer will have two representatives on Teuto's board of directors.

Under the terms of the agreement, Pfizer will make an upfront payment of R$400 million (approximately US$240 million) and Teuto will be eligible to receive a performance-based milestone payment. Pfizer has an option to acquire the remaining 60 percent of Teuto's shares beginning in 2014. Teuto's shareholders have an option to sell their 60 percent stake to Pfizer beginning in 2015. [I.e. the deal has both a call option by PFE and a put option by Teuto’s shareholders.]

Pfizer will have the opportunity to register and commercialize Teuto products in Brazil and various markets outside of the country under its own brands, including branded and unbranded generic medicines, covering a broad range of therapeutic areas, such as pain and inflammation, cardiovascular, anti-infectives, central nervous system and respiratory, among others. Teuto will gain access to select Pfizer products for distribution across its extensive distribution network and have the right to commercialize them under Teuto's own brand in Brazil.

In 2008, the global generics marketplace represented US$750 billion and is anticipated to grow up to US$920 billion by 2013, with the bulk of this growth generated in emerging markets. Today, branded and unbranded generics account for approximately 60 percent of the value of the Brazilian retail pharmaceutical market fueled by the increased purchasing power of growing middle and lower-middle income patients [i.e. The Global Demographic Tailwind].

"We believe this partnership will enable both companies to effectively build upon one another's core capabilities and areas of expertise to help address the needs of more patients than ever before," said Jean-Michel Halfon, president of Pfizer's Emerging Markets Business Unit. "This agreement demonstrates Pfizer's commitment to pursue focused investments in key emerging markets to accelerate our growth and increase patient access to high-quality medicines."

"Teuto's partnership with Pfizer is very complementary to our business goals. It will expand our product portfolio and address the needs of the changing customer base," said Marcelo Henriques, chief executive officer of Teuto Laboratories.

The stake in Teuto demonstrates Pfizer's commitment to continue its expansion in emerging markets through customer-focused efforts by increasing access and affordability, partnering with other companies that offer diverse areas of expertise and leveraging the company's capabilities to build upon local markets.

The transaction is subject to customary closing conditions and is expected to close by the end of fourth-quarter 2010.

Pfizer's financial advisor for the transaction was Goldman Sachs Group, Inc. while Skadden, Arps, Slate, Meagher & Flom LLP and Pinheiro Neto Advogados were its legal advisors. Banco BTG Pactual SA served as Teuto's financial advisor, while Machado, Meyer, Sendacz & Opice and Cleary Gottlieb served as legal advisors.‹