Replies to post #38866 on NanoViricides Inc. (NNVC)

[NNVClover]

I'm only talking about antivirals, not vaccines.

Mice were not used in the development of NRTIs, NNRTIs and protease inhibitors.

http://www.ncbi.nlm.nih.gov/pubmed/2886549

HAART was done the way I suggested it was done. Your links are nothing more than fringe experimental work. The standard protocol excludes mice for obvious reasons.

[NNVClover]

You have a very poor attitude about you. I'm not trying to attack you.

Mice don't have reverse transcriptase. This makes them EXTREMELY POOR candidates for studying viral diseases. Wildly, terribly poor candidates. All of the data generated thus far with our Nanoviricides has been non-human. Without human data we can't rely too much on mice data or in vitro since there is such a poor correlation to success. Unlike other diseases where animal models are reliable, virology is a bit of a crap shoot since ADME/tox is pretty much all you can predict. Design a good drug that will be absorbed and circulated, and hope you got the metabolism right.

There hasn't been a new NRTI in a decade because once the crystal strucutre is solved you simply only have a few avenues to go down.